Jessica Faulkner, Pediatric Nephrology Series Join Facebook to connect with Jessica Faulkner and others you may know. All rights reserved, Why young females with obesity are at early risk for cardiovascular disease, New evidence that females might benefit most from a low-salt diet, Scientists work to protect obese, younger women from cardiovascular risk, Women voters say health care is on the line this year — and they aren’t hearing enough about it, The Pandemic Is Devastating Women and Could Make It Harder for Them to Vote, 2020 Women Voters Are Fired Up This Election, On Covid, Economy And Climate. Priti Meena, MD (TIF), Metabolic cage data from CalOE and tTA control mice fed a normal salt diet before and after DOX treatment (20 mg/ml in drinking water) for one and two weeks (n = 6–8, * indicates P< 0.05 vs. tTA control mice). Leonardo Riella, MD (Kidney Transplantation), Faculty Advisors The links below are powered by Bing search results. Nikhil Agrawal, MD Additional information is available in this. She is an actress, known for Glitch (2015). In healthy pregnancy, relaxin plays an important vasodilatory role to maintain vascular compliance; however, there is currently no preclinical evidence to support the use of relaxin during preeclampsia. IN, MAILING ADDRESS: 1120 15th Street, Augusta, GA 30912, Professor, Department of Pharmacology & Toxicology, Vascular Biology Center, Professor, Vivian L. Smith Chair in Regenerative Medicine, Texas Heart Institute, Sr. Postdoctoral Fellow, Vascular Biology Center, Assistant Professor, Department of Pediatrics, McGovern Medical School, University Jessica FAULKNER, Post-Doctoral Fellow of Augusta University, GA | Read 51 publications | Contact Jessica FAULKNER It is accompanied by chronic inflammation, intrauterine growth restriction, elevated anti-angiogenic factors, and can occur with or without proteinuria. However... Leptin is the current treatment for metabolic disorders associated with acquired and congenital generalized lipodystrophy (CGL). We showed that on a high salt diet (4% NaCl), female mice increase adrenal CYP11B2 (the aldosterone synthase enzyme) expression and do not suppress plasma aldosterone, in contrast to male mice. To review the latest reports of the contributions of the endothelial mineralocorticoid receptor to endothelial dysfunction and hypertension to begin to determine the clinical potential for this pathway for hypertension treatment. Preethi Sekar, MD Additionally, we demonstrated in this report that pregnant mice exhibit an upregulation of endothelial MR expression in association with high progesterone levels in pregnancy. Progesterone Reduces Endothelial Function Without Increasing Endothelial Mineralocorticoid Receptor Expression in Male C57Bl/6 Mice, HIV Increases Basal Metabolic Rate, Impairs Endothelial Function and Elevates Blood Pressure in Male and Female Mice, Low Salt Diet Elevates Aldosterone Levels and Induces Endothelial Impairment in a Sex‐and Strain‐Dependent Manner in Mice, Endothelial Mineralocorticoid Receptor Deletion Abrogates Leptin‐Induced Endothelial Dysfunction in Pregnant Mice, Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females, Sex hormones, aging and cardiometabolic syndrome, 17-Hydroxyprogesterone caproate improves T cells and NK cells in response to placental ischemia; new mechanisms of action for an old drug, Leptin Restores Endothelial Function via Endothelial PPARγ-Nox1–Mediated Mechanisms in a Mouse Model of Congenital Generalized Lipodystrophy, Mineralocorticoid Receptor and Endothelial Dysfunction in Hypertension, Abstract 121: Leptin Restores Endothelial Function, Diminishes Vascular Adrenergic Contractility, but Does Not Alter Arterial Stiffness and Blood Pressure, in a Mouse Model of Congenital Generalized Lipodystrophy, Abstract 007: Endothelial Mineralocorticoid Receptors are Increased by Pregnancy in Mice and Mediate Obesity-Associated, Leptin-Induced Endothelial Dysfunction in Pregnancy, Progesterone Predisposes Females to Obesity-Associated Leptin-Mediated Endothelial Dysfunction via Upregulating Endothelial MR (Mineralocorticoid Receptor) Expression, Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain, Lack of Suppression of Aldosterone Production Leads to Salt-Sensitive Hypertension in Female but Not Male Balb/C Mice, Abstract 096: Progesterone Upregulates Endothelial Mineralocorticoid Receptor Expression Which Predisposes Female Mice to Obesity-Induced Endothelial Dysfunction, Abstract P140: Leptin Supplementation Restores Endothelial Function and Vascular Adrenergic Tone via Direct Endothelial Mechanisms and Sympato-Activation, Respectively, in a Mouse Model of Congenital Lipodystrophy, Identification of novel macropinocytosis inhibitors using a rational screen of FDA-approved drugs, Abstract 100: High-throughput Screening of FDA-approved Drugs Identifies Novel Inhibitors of Macropinocytosis, Arachidonic acid metabolites of CYP4A and CYP4F are altered in women with preeclampsia, Sex Differences in Mechanisms of Hypertension Associated With Obesity, The regulation of aldosterone secretion by leptin: Implications in obesity-related cardiovascular disease, Continued Investigation Into 17-OHPC: Results From the Preclinical RUPP Rat Model of Preeclampsia, Selective inhibition of 20-hydroxyeicosatetraenoic acid lowers blood pressure in a rat model of preeclampsia, Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy, Vitamin D supplementation reduces some AT1-AA induced downstream targets implicated in preeclampsia including hypertension, Serelaxin improves the pathophysiology of placental ischemia in the Reduced Uterine Perfusion Pressure (RUPP) rat model of Preeclampsia, Identifying Immune Mechanisms Mediating the Hypertension During Preeclampsia, Placental Ischemia and Resultant Phenotype in Animal Models of Preeclampsia, The role of inflammtion in the pathology of preeclampsia, 181: Administration of 17-hydroxyprogesterone caproate in mid-gestation improves fetal growth possibly by reducing sFlt-1 and placental cytolytic NK cells in the Reduced Uterine Perfusion Pressure (RUPP) rat model of Preeclampsia, 475: Blockade of 20-HETE synthesis improves blood pressure and fetal survival in the RUPP rat model of preeclampsia, Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia, Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice, IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia.
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